Department of Biochemistry, University of Toronto, Canada
Mini Review
Delivery of Cd47-Targeted Drugs with Precision and the Invention of Anti-Phagocytic Delivery Systems: The Cd47-Sirp Axis in Cancer Therapy
Author(s): Anup Tiwari*
Humans, mice, and other mammals express CD47 as a "marker of self" on the surface of every cell to prevent the phagocytic death of healthy cells by connecting with signal regulating protein on macrophages and dendritic cells and conveying a "don't eat me" signal. Unfortunately, a variety of cancer cells use this "don't eat me" signal to their advantage by overexpressing CD47 on their surface in order to circumvent immune surveillance and macrophage detection. As a result, blocking the CD47-SIRP axis may be a promising therapeutic target for the treatment of cancer. However, because .. View More»
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 