Department of Pediatrics, Ningxia Medical University, China
Review
Young Mouse Model High-Frequency Ultrasound-Guided Intrathecal Injections: Drug Delivery That Concentrates On the Central Nervous System
Author(s): Arti Rao*
Intrathecal injections are crucial for delivering aesthetic, analgesic, or chemotherapy medications to the central nervous system because they allow them to pass the blood-brain barrier. The inability to see the tiny target zone during injection makes it difficult to administer medications via this route in animal studies. Therefore, knowledge of the indirect assessment of vertebral and spinal cord architecture as well as the acquisition of advanced procedural skills is necessary for successful medication delivery. These problems are further exacerbated in studies modelling paediatric drug administration, where the animal is significantly smaller, and in studies using small animals like mice. New approach we have created a technique that uses high-frequency ultrasound imaging to visualise and target the lumbar intrathecal region for injections in order to solve these problems. The met.. View More»
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