School of Pharmaceutical Sciences, IFTM University, Moradabad U.P, India
Research Article
Process Variable Studies for the Preparation of Optimized Drug Delivery System Using Central Composite Design
Author(s): Vijay Sharma*, Ashish Singh Chauhan and Arvind Raghav
This research work aimed to study process variable studies for the
tasteless drug resin complex of Propranolol hydrochloride and Kyron-T
314. The effect of different parameters such as swelling time, stirring
time, pH, Temperature, drug resin ratio, as well as resin activation, was
optimized by taste and percentage of drug loading. The formulation
DRC (Drug Resin Complex) was characterized by Infrared Spectroscopy.
Differential Scanning Colorimetry, and X-ray Diffraction Pattern.
Tablets were formulated by the Direct Compression method with
Hydroxypropyl methylcellulose (HPMC) as a binder. Sodium Starch
Glycolate (SSG) and Kyron-T 314 as a super disintegration, In these
batches, optimum hardness was achieved but disintegration time was
found to be 30 Seconds, so further trials were planned by using different
super disintegrants such as Sodium starch.. View More»
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