Division of Systems Biomedicine and Pharmacology, Leiden University, Iran
Case Report
Anti - proliferative medication pharmacodynamics: practical considerations for enhancing quality of care
Author(s): Bahare Salehi*
Given the high mortality rate of invasive fungal infections (IFIs), it appears essential for therapeutic efficacy and safety to receive the proper antifungal exposure. Materials and procedures: In this study, the pharmacokinetic data on systemically administered antifungals with an emphasis on target-site penetration, comorbidities, and combination antifungal therapy are summarised. Discussion and conclusions: Through the urine and faeces, amphotericin B is removed unaltered. Both flucytosine and fluconazole have a low affinity for proteins and are excreted by the kidney. The liver is where itraconazole, voriconazole, posaconazole, and isavuconazole are metabolised. Azoles are implicated in a variety of drug-drug interactions because they are substrates and inhibitors of the cytochrome P450 (CYP) isoenzymes. In the plasma, anidulafungin degrades on its own. CYP is not involved in the .. View More»
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