Mahavir Cancer Sansthan and Research Centre, Patna, Bihar-801505, India
Research Article
Anticancerous Effect of Fruit pulp of Aegle marmelos Against Benzo[A]pyrene Induced Lung Tumours in Rats
Author(s): Jyotsna Sethi*, Chandrajeet Kumar and Arun Kumar
In the recent times, the lung cancer disease burden in the population has increased manyfolds globally. Among those carcinogen- Benzo[A]pyrene is one of the known which is directly responsible for the cause. Benzo(a)pyrene has been shown to inflict damage on the lungs as well as liver. Thus, the present study has been aimed to study the anticancer activity of Aegle marmelos fruit pulp extract on Benzo [A] pyrene induced lung cancer in rats. Thirty male Charles Foster rats, 6 weeks old weighing around (150-180 g) were used for the study and were induced Benzo[A] pyrene (25 mg/Kg dissolved in Olive oil) orally in two intervals (1st day and 14th day) and were left for 3 months. After 3 months, there was development of lung tumours, which were confirmed histopathologically. Thereafter, Aegle marmelos fruit pulp extract at the dose of 250mg/Kg body weight was administered to the rats for 5.. View More»
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