Department of Cell and Molecular Biology, Grand Valley State University, Allendale, USA
Research Article
Potent Suppression of Proliferation of Breast Carcinoma Cells by a Novel Anthranilic Acid Derivative
Author(s): Alexander Fisch, Chelsea Reiber, William Schroeder, Robert Smart and Osman V Patel*
Background/objective: Chemotherapy remains the mainstay therapy for the most intrusive-type of breast carcinoma, triple-negative breast cancer (TNBC) that has a higher tendency for visceral metastases, relapses, and poor prognoses. It is well recognized that the reactivation of a ribonucleoprotein enzyme, telomerase is among the key determinants of breast carcinogenesis, cellular immortalization and metastatic progression. Therefore, our objectives were to assess (i) short- and (ii) long-term effects of a novel anthranilic acid (GV6) developed at our institute and compare it to a known analogue, BIBR1532 on TNBC (MDA-MB 231) and non-TNBC (MCF-7) cells.
Methods: Seeded TNBC and non-TNBC flasks were supplemented with 25 µM of either BIBR 1532 or GV6 or solvent (DMSO) alone for 14 (Short-term) or 27 (Long-term) days. Trypan-blue dye exclu.. View More»
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