Department of Health and communication, Egypt
Research Article
Detailed Information on Metabolic-Associated Fatty Liver Disease Involvement
Author(s): David Britez* and Craig Venter
Metabolic-Associated Fatty Liver Disease (MAFLD), formerly known as Non-Alcoholic
Fatty Liver Disease (NAFLD), is a condition characterized by the accumulation of fat in
the liver. It is strongly associated with metabolic syndrome, which includes obesity,
insulin resistance, dyslipidemia, and hypertension. MAFLD has emerged as the most
common cause of chronic liver disease worldwide.
The relationship between MAFLD and diabetes is bidirectional and complex. Diabetes
is a well-established risk factor for the development and progression of MAFLD. Insulin
resistance, a hallmark of type 2 diabetes, plays a crucial role in the pathogenesis of
MAFLD. When cells become resistant to the effects of insulin, the pancreas compensates
by producing more insulin. This excess insulin promotes lipid accumulation in the liver,
leading to the development of MAFLD... View More»
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