Department of Pharmaceutical analytical Science, GRY Institute of Pharmacy, Borawan, India
Research Article
Formulation of baclofen microemulsion and validation of analytical method for quantitative estimation by UV spectroscopy
Author(s): Patidar Mohini*, Pillai Sujit, Deshmukh Nitin, Patel Sumit and Mahajan Aakansha
Baclofen is a centrally acting skeletal muscle relaxant used to treat muscle spasticity and multiple sclerosis. Baclofen hydrophilic characteristics make it challenging for it to cross the blood brain barrier, resulting in a bioavailability of less than 60%. The current study's objectives are to develop, optimize and validate an analytical method for the quantitative estimation of Baclofen by UV-visible spectrophotometer in accordance with ICH guidelines, as well as to improve the bioavailability and efficacy of drug release by formulating micro emulsion of Baclofen. Four different batches were formulated on the bases of S/Cos ratios 3:1, 3.5:1, 4.5:1 and 1.5:1 respectively by water titration method. Tween 80, span 80 and PEG 400 were blended together to form a homogeneous mixture, Baclofen was dissolved in oil phase. Oil phase and surfactant mixture were mixed slowly with continu.. View More»
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