Vidyabharati College of Pharmacy, Amravati, India
Research Article
Formulation and Evaluation of Microsponges Loaded Topical Gel for Treatment of Acne Vulgaris
Author(s): Diksha D Ghorpade* and Dr. Atram SC
The purpose of present study aims to design novel drug delivery system containing adapalene microsponges and to prepare microsponge gel. Adapalene is an anti-acne drug used in the treatment of acne infection having a poor aqueous solubility, side effects and adverse reactions. The microsponge delivery system is unique technology for controlled/ sustained release of active agents. The microsponges were prepared by quasi-emulsion solvent diffusion method by using polymer Eudragit S-100 and Eudragit RS -100. All the formulated microsponges were subjected for various evaluation parameters such as production yield, encapsulation efficiency, particle size analysis and in vitro drug release study. The optimized microsponge formulation F4 and F8 were further formulated as gel formulation for topical delivery. Prepared gel was evaluated for physical parameters like pH, spreadability, viscosity.. View More»
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