Department of Virology, Microbiology, ABD University of Science and Technology, Pakistan
Mini Review
Candidiasis: Host Immune Response
Author(s): Dr. Mo Abdul Ahamd*
This transition is heavily reliant on an impressive repertoire of virulence factors, most notably cell surface adhesins, proteolytic enzymes, morphologic switching, and the development of drug resistance. In the oral cavity, the co-adhesion of C. albicans with bacteria is crucial for its persistence, and a wide range of synergistic interactions with various oral species were described to enhance colonization in the host. As a frequent colonizer of the oral mucosa, the host immune response in the oral cavity is oriented toward a more tolerogenic state and, therefore, local innate immune defenses play a central role in maintaining Candida in its commensal state. Specifically, in addition to preventing Candida adherence to epithelial cells, saliva is enriched with anticandida peptides, considered to be part of the host innate immunity. The T helper 17 (Th17)-type adaptive immune response.. View More»
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