Clinical Microbiology Research Center, Shiraz University of Medical Sciences, India
Editorial
Structure, Replication of Rotavirus and Effects of Vaccination
Author(s): Dr. Ujala Desai*
In children under the age of five, rotavirus infections are the most common cause of severe, dehydrating gastroenteritis. Over a decade after the worldwide introduction of rotavirus vaccinations, more than 200,000 people die annually from rotavirus infections, most of who occur in low-income nations. The enteric nervous system is activated, intestinal secretion is stimulated by rotavirus non-structural protein 4, and absorptive enterocytes are destroyed, resulting in malabsorption, when rotavirus infects enterocytes. Rotavirus infections can also cause viraemia and antigenaemia, both of which are linked to more severe symptoms of acute gastroenteritis. Rotavirus can also replicate in systemic sites, but this is rare. Reinfections with rotavirus are normal over the course of life, albeit the illness seriousness is diminished with rehash diseases. Although rotavirus-specific immunoglobu.. View More»
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