Department of Pathology and Laboratory Medicine, Kabale University, P.O. Box 317, Kabale, Uganda
Review Article
An Update on Interferon Gamma and C
Reactive Proteins in Sickle Cell Anaemia Crisis
Author(s): Emmanuel Ifeanyi Obeagu*, Emmanuel Muhimbura, Byamungu Pahari Kagenderezo, Onyekachi Splendid Uwakwe, Sarah Nakyeyune and Getrude Uzoma Obeagu
Sickle cell disease has been described by many scholars as a chronic inflammatory disease which is linked to many factors such as endothelial destruction, increased synthesis of reactive oxygen specie, haemolysis, increased synthesis of pro inflammatory cytokines among others. Inflammatory process play a major function in the activation of acute painful vaso-occlusion crisis that forms the main reason for the hospitalization of patients with sickle cell anaemia. Inflammatory processes, are key components of several complications of the disease including autosplenectomy, acute chest syndrome, pulmonary hypertension, leg ulcer, nephropathy and stroke and also ultimately initiates painful vaso-occlusion episodes that characterize Sickle Cell Disease. This study titled “Update on Interferon Gamma and C Reactive Proteins in Sickle Cell Anaemia in Crises, aims at finding out the recen.. View More»
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