Department of Clinical and Toxicological Analysis / Federal University of Rio Grande do Norte (DACT/UFRN), Brazil
Research Article
Clinical Significance of Flow Cytometry Findings in Brazilian Patients with De Novo Acute Myeloid Leukemia
Author(s): Linduarte Varela de Morais, Rafael Duarte Lima, Erica Aires Gil, Aldair de Souza Paiva, Lenilton Silva da Silveira Junior, Victor de Lima Soares, Ciro Alexandre Merces Goncalves, Taissa Maria Moura de Oliveira, Dany Geraldo Kramer Cavalcanti e Silva, Gustavo Henrique de Medeiros Oliveira and Geraldo Barroso Cavalcanti Junior*
Introduction: Immunophenotyping by Flow Cytometry (FC) is an essential method for diagnosis and classification of Acute Myeloid Leukemias (AML), and its extensive use could identify blast cell subpopulations with phenotypes rarely seen in normal myelopoiesis, correlating with clinical, morphological and prognostic characteristics.
Methods: In this study we analyzed 143 cases of AML, examining them for Leukemia-Associated Immunophenotype (LAIP) by FC immunophenotyping in leukemic cells using a panel of monoclonal antibodies (MoAb) for diagnosis and classification of Acute Leukemia (AL). At the same time, clinical, demographic and hematological data of these patients were also investigated. Most patients were male adults and splenomegaly and hepatomegaly were present in most cases.
Results: Immunophenotyping showed a.. View More»
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