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Annals of Clinical and Laboratory Research

  • ISSN: 2386-5180
  • Journal h-index: 19
  • Journal CiteScore: 5.42
  • Journal Impact Factor: 4.64
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
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Frederique Ponchel

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Chapel Town Rd, Leeds LS7 4SA, United Kingdom

Publications
  • Mini Review   
    Differential CpG DNA Methylation: qMSP a Promising New Approach towards Clinical Utility as Biomarkers
    Author(s): Frederique Ponchel*, Rujiraporn Pitalsalee and Thomas Sargent

    Epigenetics modifications were shown to be directly related to disease pathogenesis as well as particular stages of their progression. Epigenomic profiles or specific epigenetic changes therefore have the potential to be used as biomarker for diagnosis, prognosis and prediction of response to treatment or stratification towards advancing personalised medicine. DNA-methylations on CpG-dinucleotide regulate the chromatin structure by modulating nucleosomes spatial distribution and controlling DNA packaging. Profiling DNA-methylation genome-wide has allowed for disease or event/outcome specific CpG to be identified. Quantitative Methylation Specific qPCR (qMSP) are assays targeting a specific change in the methylation status of a CpG-dinucleotide. .. View More»

    Abstract PDF