Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Chapel Town Rd, Leeds LS7 4SA, United Kingdom
Mini Review
Differential CpG DNA Methylation: qMSP a Promising New Approach towards Clinical Utility as Biomarkers
Author(s): Frederique Ponchel*, Rujiraporn Pitalsalee and Thomas Sargent
Epigenetics modifications were shown to be directly related to disease pathogenesis as well as particular stages of their progression. Epigenomic profiles or specific epigenetic changes therefore have the potential to be used as biomarker for diagnosis, prognosis and prediction of response to treatment or stratification towards advancing personalised medicine. DNA-methylations on CpG-dinucleotide regulate the chromatin structure by modulating nucleosomes spatial distribution and controlling DNA packaging. Profiling DNA-methylation genome-wide has allowed for disease or event/outcome specific CpG to be identified. Quantitative Methylation Specific qPCR (qMSP) are assays targeting a specific change in the methylation status of a CpG-dinucleotide. .. View More»
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