Department of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italy
Mini Review
Rodent Models of Huntington's Disease: An Overview
Author(s): Gallilio Fernadez*
Huntington's Disease (HD) is a progressive neurodegenerative disorder
characterized by motor dysfunction, cognitive decline, and psychiatric
symptoms. It is caused by a genetic mutation that leads to an abnormal
expansion of CAG repeats in the Huntingtin (HTT) gene, resulting in an
expanded polyglutamine tract in the huntingtin protein. This mutation
induces a cascade of cellular dysfunctions culminating in the death
of specific neuronal populations, predominantly in the striatum and
cortex. While human studies provide critical insights, animal models,
particularly rodent models, have been invaluable for understanding the
pathophysiology of HD and for developing therapeutic strategies... View More»
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 