The Chicago Medical School - Rosalind Franklin University, USA
Short Communication
Calcium signaling in the CNS in health and neurodegenerative disease
Author(s): Grace E Stutzmann*
Statement of the Problem: A shared aspect among many neurodegenerative disorders is a limited understanding of cellular disease mechanisms. In our research, we have found that dysregulated calcium channels play a central and early role in driving diseases such as Alzheimer’s, Huntington’s and brain injury. Specifically, defects in intracellular calcium stores within the endoplasmic reticulum (ER) and their resident release channels such as the ryanodine receptor (RyR) are upstream of the major disease features such as protein aggregates and synaptic deficits. By focusing upon the proximal calcium channelopathy, rather than later-stage features, significant advances in understanding disease etiology may be made
Methodology & Theoretical Orientation: Whole cell patch clamp electrophysiology combined with 2-photon calcium imagin.. View More»
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