Division of Medical Engineering Research, National Health Research Institutes, Miaoli, 350, Taiwan
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Micro RNAs' roles in coronary artery disease and revascularization
Author(s): Graciela Carlos*
The vascular wall's chronic inflammatory response is commonly regarded as atherosclerosis, and its complications contribute significantly to patient mortality. Patients with atherosclerotic disease frequently undergo an angioplasty with stent replacement. However, angioplasty patients typically experience a high rate of restenosis. New signalling molecules that regulate the progression of atherosclerosis and restenosis have continuously been discovered, despite the well-established pathophysiological mechanisms that underlie these conditions. A new class of gene regulators known as microRNAs (miRs) function through translational inhibition or activation and transcriptional degradation
More than 30% of the cell's genes can be directly controlled by miRs. As a result, it is accepted that miRs play a crucial role in normal development, physiology, and pathogenesis. Dive.. View More»
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