Physiology Department, Faculty of Basic Medical Science, Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Oyo State, Nigeria
Research Article
COMPLEXATION, CHARACTERIZATION, AND TOXICOLOGY STUDIES OF THE CRUDE EXTRACT OF ANACARDIUM OCCIDENTALE LEAVES AND ITS COPPER (II) COMPLEX
Author(s): Akinola Dolapo Esther, Oladipo Adelaide Mary, Ajao Folasade Omobolanle* and Iyedupe Marcus Olaoye
Aim and objective: The search for effective therapy for diabetes mellitus is still unattainable. This study investigated anti-diabetic effect of Anacardium Occidentale Ethanolic leaves extract and Ethanolic leaves extract complex copper (II) in alloxan-induced diabetic rats.
Method: Fifty six matured male Wistar rats (200-250g) were used. Alloxan monohydrate (65 mg/kgb.wt) was singly injected intraperitoneally to induced diabetes. The animals were randomly alienated into 7groups, 8rats/group. Group I: normal control; Group II: diabetic; Group III & IV: diabetic rats + 400 mg/kgb.wt and 600 mg/kgb.wt A. Occidentale Ethanolic crude leaves extract; Group V and VI: diabetic rats + 400 mg/ kgb.wt and 600 mg/kgb.wt Ethanolic leaves extract complex copper (II); Group VII: diabetic rats + 500 mg/kgb.wt metformin for 15 days. Body weight and fasting blood glucose (FBG) were recor.. View More»
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