Department of Oncology, University of Glasgow, Scotland, United Kingdom
Short Communication
Gastric Carcinoma: Recent Trends in Diagnostic Biomarkers and Molecular Targeted Therapies
Author(s): Jack James*
Gastric cancer is generally associated with poor survival rates
and accounts for a remarkable proportion of global cancer
mortality. The prevalence of gastric carcinoma varies in
different regions of world and across the various ethnic
groups. On the basis of pathological assessment, gastric
cancer can be categorized as intestinal and diffuse
carcinomas. The etiology is diverse, including chemical
carcinogen exposure and high salt intake Helicobacter pylori also plays a vital role in the pathogenesis of certain gastric
carcinomas. The development of gastric cancer involves
various alterations in mRNAs, genes (GOLPH3, MTA2) and
proteins (Coronins). miRNAs, Hsamir135b, MiR21, miR106b,
miR17, miR18a, MiR21, miR106b, miR17, miR18a and
MiRNA375, miRNA1955p are the latest diagnostic biomarkers
which can facilitate the early diagnosis .. View More»
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