Radiotherapy and Carcinologic Laboratory, CHU Habib Bourguiba Sfax, Sfax, Tunisia
Research Article
Significant Value of p53 Accumulated in Invasive Ductal Breast Carcinoma
Author(s): Sami Baccouche*, Ahmed Rebai, Mounir Frikha, Jamel Daoud, Rachid Jlidi and Ali Gargouri
Background: The presence of a functional p53 protein is a
key factor for the appropriate suppression of cancer
development. The tumor suppressor p53 accumulates
under stressful conditions, such as DNA damage, heat
shock, hypoxia and/or proto-oncogene activation, although
conflicting reports exist on its transcriptional activity. A loss
of p53 activity, by mutations or inhibition, is often
associated with human malignancies. This work investigated
the significant value of p53 accumulated in IDBC (Invasive
Ductal Breast Carcinoma) and at the same time tries to arise
different supports of this value.
Results: To ensure this objective, we referred to two types
of statistical analysis, the chi-square and logistic regression
analysis. They confirmed the poor prognosis of p53
accumulated in IDBC (β.. View More»
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