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Archives in Cancer Research

  • ISSN: 2254-6081
  • Journal h-index: 14
  • Journal CiteScore: 3.77
  • Journal Impact Factor: 4.09
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
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Jamel Daoud

Department of Biology and Geology, Preparatory Institute to Engeneiring Study, Sfax, Tunisia

Publications
  • Review Article   
    What are the Different Cross Talks between HIF1-?, TGF?, Integrin and ECM in Mediating Breast Cancer?
    Author(s): Sami Baccouche*, Nejla Fourati, Wissem Siala, Rachid Jlidi and Jamel Daoud

    Extracellular Matrices (ECM) serve as the molecular scaffold for cell adhesion, migration, proliferation and differentiation and as a repository of cytokines and molecular cues that determine cell polarization and tissue organization. The EMC alteration conducts to Integrin β3 regroupement, after its TGFβ induced overexpression; important tumorogenesis step that mediates an amplified integrin-Fak-Src signaling leading to aggressive tumor phenotype. The upstream of these events is the accumulation of stress sensor protein, HIF-1α, which in involved in a constitutive active TGFβ overexpression, epigenetic landscape remodeling and sustaining a Smad2/3 signaling by supressing VHL expression. Together, allowed TGFβ late target genes expression such as: SNAIL, MMP, galectin, paxillin and integrinβ3; and at the same time TGFβ early genes repressi.. View More»

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