KU Leuven, Belgium
Short Communication
Functional properties of the IP3 receptor at membrane contact sites
Author(s): Jan B Parys*
Statement of the Problem: The inositol 1, 4, 5-trisphosphate (IP3) receptors (IP3Rs) are ubiquitously expressed Ca2+ release channels of the endoplasmic reticulum (ER). Th e resulting Ca2+ signals are instrumental in the regulation of many intracellular processes. It is now becoming increasingly clear that contact sites between ER and mitochondria or between ER and lysosomes is very important for controlling mitochondrial energetics, autophagy and apoptosis. Anti-apoptotic Bcl-2 leads to increased cell survival by both blocking pro-apoptotic family members like Bax and Bak and by inhibiting IP3R mediated Ca2+ transfer to the mitochondria. As Bcl-2 is upregulated in a variety of cancers, including diff use large B-cell lymphoma (DLBCL) and chronic lymphocyticleukemia (CLL), we developed in collaboration with Clark W Distelhorst (Case Western Reserve University, USA) BI.. View More»
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