Emergency Physician, Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia
Research Article
Development of Neurotoxicity Syndrome Associated With the Use of Cefepime
Author(s): Jhon Fredy Bello Cordero*
Cefepime is a broad-spectrum antibiotic; belonging to the group of fourth-generation cephalosporin’s commonly used in the hospital setting for the management of multiple infections. Due to mechanisms not well elucidated to date, it is capable of crossing the blood-brain barrier and causing adverse neurological effects when its plasma concentration rises, mainly in those patients in whom its dosage adjusted to creatinine clearance or creatinine clearance is not taken into account. Kidney functions if it is compromised. Also, cases have been reported in which patients with adequate renal function may present this heterogeneous presentation syndrome. The comprehensive management of the patient with this clinical presentation starts from prevention, correct dosage, and timely follow-up and early recognition of the Etiology of the neurological condition to obtain the best possible re.. View More»
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