Department of Chemical Pathology, Edo State University Uzairue, Edo State, Nigeria
Research Article
Serum Antioxidant Status of Induced Preeclamptic Wistar Rats Exposed to Methanolic Leaf Extracts of Some Selected Herbal Plants
Author(s): Kenneth Atoe* and MacDonald Idu
Preeclampsia is known to cause an accumulation of free radicals, putting the cells in a state of oxidative stress. Antioxidants are produced by cells as a defense mechanism against these stressors. Antioxidants are natural chemicals that can prevent or postpone various types of cell damage by acting as oxidative process inhibitors. Food and medicinal plants are the primary sources of antioxidants. The goal of this study was to see how methanolic leaf extracts of Jatropha curcas, Alchonnea cordifolia, and Secamone afzelii affected the antioxidant state in induced preeclamptic Wistar rats. Age-matched female Wistar rats weighing 220 to 256 g were used for the study. Preeclampsia was induced using the Adriamycin Model. When preeclampsia was confirmed in the induced Wistar rats by an increase in blood pressure from 124/98 mmHg to 177/121 mmHg, as well as significant proteinuria, the preec.. View More»
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