Immanuel Kant Baltic Federal University, Russia
Short Communication
Visfatin/NAMPT expression in adipose tissue of obese patients with and without type 2 diabetes
Author(s): Litvinova Larisa*
Introduction: Visfatin has multidirectional effects-proinflammatory, stimulating the production of pro-inflammatory cytokines, and neuro-, angioprotective properties. Adipokine has an insulin-mimetic effect and stimulates insulin production. In this regard, the aim of the study was to study the role of visfatin in the development of type 2 diabetes in patients with obesity.
Methodology & Theoretical Orientation: Serum glucose levels were determined using a biochemistry analyzer. Using the method of flow fluorimetry, the content of visfatin, insulin and leptin in the blood plasma was determined using commercial test systems; gene expression level - by PCR.
Findings: In the group of obese patients with type 2 diabetes, the content of leptin, insulin and glucose in the blood plasma was higher, which was the case f.. View More»
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