Department of Oncology, University of Hospital Zurich, Switzerland
Mini Review
Challenges in Promoter Methylation Research by Translational Oncology
Author(s): Lucia Agarwal*
Epigenetic changes have frequently been suggested for the diagnosis and creation of anti-cancer therapy techniques in the search for novel trustworthy biomarkers [1]. In fact, promoter methylation has to be paired with a highly informative technology that is tested in a suitable biospecimens for it to actively become a tumour marker for therapeutic application [2]. In fact, one of the most difficult issues in epigenetic research is methodological uniformity [3]. Additionally, liquid biopsy is being used to supplement and, in some situations, replace tissue-based biopsy [4]. This study will emphasise the improvements made for the prospective use of methylation biomarkers in clinical settings, with a focus on liquid biopsy, for both pre-analytical and analytical application [.. View More»
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