Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University and Qunfudh Medical College,Umm Al-Qura University, Makka, Saudi Arabia
Short Communication
Effect of omeprazole, pantoprazole and famotidine on rat bones
Author(s): Dina Salem, Elhamy El-Kholy, Hala Abdel Malak, Abdelhadi M Sheb and Mahmoud Abdalla
Background: Osteoporosis is the most common age-related skeletal chronic disorder. The use of acid-suppressive drugs (especially: proton pump inhibitors; PPIs and H2 receptor blockers; H2RAs) is widespread in osteoporotic patients. to counteract inflammation and ulceration of esophagus and stomach caused by prolonged use of anti-resorptive medications bisphosphonates especially fracture risk While, others have not observed any fracture risk with the use of PPIs . The data on the effects of H2RAs are conflicting too. These drugs can reduce gastric acid secretion by up to 98% , irreversibly deactivating the proton pump (H+/K+ ATPase) of the gastric parietal cells. H2RAs (cimetidine, ranitidine, famotidine) competitively inhibit H2 receptors, have similar effects to PPIs, although they are less potent, blocking only 70% of gastric acid production . It has been suggested .. View More»
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