Department of Neuroradiology, Karolinska University Hospital, 171 76 Stockholm, Sweden
Mini Review
A case report of lethal cerebral encephalocele and antiphospholipid antibiotic response following SARS-CoV-2 vaccination
Author(s): Mattia Iacobaeus*
Acute hemorrhagic encephalomyelitis (AHEM) is a relatively
uncommon hyperacute form of acute disseminated encephalomyelitis
(ADEM). The disease is distinguished by fulminant inflammation
and demyelination of the brain and spinal cord, and it is frequently
preceded by an infection or vaccination. A 53-year-old man with
rheumatoid arthritis and ongoing methotrexate and etanercept
treatment developed fatal AHEM after receiving the second dose
of the COVID-19 vaccine. Multiorgan thromboembolic disease
complicated the disease course, as did the presence of high/moderate
levels of cardiolipin IgG antibodies and anti-beta-2 glycoprotein 1
IgG antibodies, indicating a possible antiphospholipid syndrome.
Immunosuppressive therapy failed to improve the situation.
Comprehensive clinical, neuroimaging, and neuropathological findings
are included.. View More»
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