Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, 31982 Al-Ahsa, Saudi Arabia
Research Article
New Nano-Based Drug Delivery Systems for Hepatic Stellate Cells in the Fibrotic Liver
Author(s): Mohamed Mohsin*
Hepatic stellate cells (HSCs), which are phenotypically activated and have a phenotype mimicking myofibroblasts, are found in the perisinusoidal region of the liver, This phenotypic transformation also results in the accumulation and production of various extracellular matrix (ECM) proteins in the perisinusoidal space, as well as altered hepatic function, portal hypertension, increased vascular resistance, fibrosis, cirrhosis, and hepatocellular carcinoma. Activated HSCs and myofibroblasts are the primary collagen-producing cells in the wounded liver. HSCs are hence frequently the subject of fibrosis therapies. Antifibrotic nanomedicines often target HSCs with vitamin A decoration since they house the majority of the body's retinol. By preventing fibrogenesis and the production of genes related to the extracellular matrix (ECM), vitamin A-decorated nanomedicines containing siRNAs .. View More»
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