National Centre of excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, Pakistan
Review Article
Development of new anticancer virus-based treatments: A comprehensive review
Author(s): Namra Ahmad, Muhammad Hamza Ashraf*, Nazim Hussain*, Muhammad Ikram Ramzan, Qandeel Bajwa, Sidra Manawar, Muhammad Rizwan Ali, Muhammad Asif Muneer, Muhammad Zafar Saleem and Syed Muhammad Asad Ali
Oncolytic virotherapy has turned into a noteworthy cancer therapeutic approach, preferentially targeting and killing cancerous cells without affecting healthy cells. Oncolytic viruses' propensity to proliferate specifically in tumor cells results in rapid cell disruption and the development of an aggressive antitumor immune reaction. The advances in molecular biology and biotechnology approaches for genetic manipulation of recombinant viruses for clinical applications have made real progress. Modifications in the genetic sequence of oncolytic viruses can enhance cell-targeting efficacy. This evolving research has resulted in improvements in the efficacy and specificity of OVs as an alternative therapeutic approach for malignant tumours, albeit with significant methodological flaws. Nevertheless, it has become obvious that oncolytic viruses alone may not be able to offer a comprehe.. View More»
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