Department of pharmacology and pharmacokinetics education, Zambia
Book Review
Update on Rhein Pharmacological Activities, Security, and Pharmacokinetics
Author(s): Paul Grignard*
One of the primary active ingredients in rhubarb and Polygonum multiform is rhein, which is an anthraquinone molecule. Rhein has a wide range of pharmacological benefits, including effects that protect the heart and brain, hepatoprotect the liver, protect the kidneys, reduce inflammation, fight tumours, and control blood sugar. The system, which includes NF-B, PI3K/Akt/MAPK, p53, mitochondrialmediated signalling pathway, oxidative stress signalling pathway, and others, is interconnected and complex. However, due to its weak water solubility and low bioavailability, its therapeutic applicability is rather constrained. Rhein may also be harmful to the liver and kidneys. Therefore, in order to serve as a guide for the creation and use of rhein, the pharmacological effects of rhein and its mechanism, pharmacokinetics, and safety investigations were examined in this work.
Rheum p.. View More»
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 