University of Western Ontario, Canada
Short Communication
Structural elements of stromal interaction molecule mediated store operated calcium entry regulation
Author(s): Peter B Stathopulos*
Calcium (Ca2+) is a universal signaling entity in eukaryotic cells mediating diverse processes such as the immune response, hypertrophy, apoptosis, platelet aggregation and memory, to name a few. These processes require a sustained elevation of cytosolic Ca2+ levels which is facilitated by store operated Ca2+ entry (SOCE). SOCE is the process whereby endoplasmic reticulum (ER) luminal Ca2+ depletion signals the opening of ion channels on the plasma membrane (PM) which facilitate the movement of Ca2+ down the concentration gradient from the extracellular space into the cytosol. Th e principal molecules that mediate SOCE include the ER resident stromal interaction molecule-1 (STIM1) and PM ORAI1 protein subunits which assemble into a channel pore. Upon ER luminal Ca2+ depletion, STIM1 undergoes a destabilization coupled oligomerization which leads to translocation of this Ca2+ sensor to.. View More»
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