Division of Cardiovascular Surgery, Gaslini Institute, IRCCS, Largo G Gaslini, Genoa, Italy
Mini Review Article
Prophylactic dexamethasone in pediatric open heart surgery PTX3 blood pentraxin elevations: Potential clinical significance
Author(s): Prigione Ignazia*
Administration of glucocorticoids before Cardio Pulmonary Bypass (PCB) may
reduce the systemic inflammatory response and improve clinical outcomes.
Pentraxin long PTX3 is a novel inflammatory parameter that may play a
cardioprotective role by modulating inflammation. 29 children undergoing
open heart surgery were enrolled in the study. Fourteen children received
dexamethasone (first dose 1.5 mg/kg IV or IM one day before surgery; second
dose 1.5 mg/kg IV before initiating bypass surgery) and fifteen children were used
as controls. Blood PTX3, short C Reactive Protein (CRP), Interleukin-1 Receptor
II (IL-1RII), fibrinogen, and Partial Thromboplastin Time (PTT) were measured at
different time points. PTX3 levels were significantly increased during CPB in both
Dexamethasone (+D) and Dexamethasone (-D)-treated and Non-Dexamethasone
(-D)-treated subjects, b.. View More»
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 