Health science and medicine Karolinska Institute, Sweden
Case Report
According to Person to the Citizenry: Including Birthrate Geographic Diversity in Experimental Studies of Pharmacology
Author(s): Rituparna Maiti*
Due to a variety of circumstances, including previous and ongoing stressors, age, sex, and genetic make-up, humans react to chemical exposures differently. However, the impact of population-level variability within dose-response relationships has not been taken into account in the great majority of laboratory-based toxicity research. Risk assessment is made more difficult by the absence of information on how genetic variety affects how the body reacts to chemical exposure since everyone in the population will react differently to toxicant exposure. Notably, genetic variety is becoming increasingly important in laboratory models because it significantly influences how people' responses to drugs or chemicals vary at the population level. Here, we provide numerous assay models that can be utilised in laboratories. genetically different cell lines, human primary cells, and genetically.. View More»
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