Department of Microbiology, Abbottabad University of Science and Technology, Pakistan
Review Article
The Public Health and Clinical Importance of Amoebiasis
Author(s): Rizwan Ullah*, Azam Hayat and Iqra Jehangir
Amoebiasis also called amoebic dysentery, first described by Fedor A. Lösch in 1875, caused by Entamoeba histolytic has great clinical impotence and is of public health significance. Histolytica has a simple life cycle involving the infective cyst that ingested through contaminated food and water and vegetative trophozoite. The pathogenesis of Entamoeba histolytica have different events like cell death, inflammation, and invasion which are performed with the help of different molecules like lectin, Amoeba pores and cysteine protease, etc. 80-90% of people infected with Entamoeba histolytica are asymptomatic (intraluminal amoebiasis) and remaining to develop manifestation like amoebic colitis, toxic megacolon, ulceration, ameboma and another extraintestinal amebiasis like amoebic liver abscess, pulmonary, cardiac and cerebral abscesses if trophozoite reaches haematogenous to these.. View More»
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