Department of Neuro-psychiatry, Faculty of Medicine, Ain Shams University, Egypt
Research
Antipsychotic-induced Changes in Blood Levels
of Leptin and Ghrelin in Schizophrenia: A Short-term
Prospective Study
Author(s): Waleed H Osman*, Nadia YS Morcos, Safeya M Effat and Naglaa S Sherif
Background: Schizophrenia (SZ) is a psychotic disorder with a complex pathophysiology. It requires long term treatment with antipsychotics (APs) which are associated with metabolic syndrome.
Aim of the study: To assess the effect of three widely-used APs, namely olanzapine (OLZ), quetiapine (QUET), and risperidone (RIS) on body weight, and its relation with appetite hormones, metabolic markers, and oxidative stress, in SZ AP-naïve men.
Subjects and Methods: 25 Patients were recruited and investigated in a functional follow-up analysis for 8 weeks. Critical changes in body weight as well as in leptin, ghrelin, glucose, lipid profile and oxidative stress markers were examined as a function of duration of AP exposure. Fifteen healthy men were included as controls.
Results: At baseline, .. View More»
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