Drug analysis/forensic toxicology, Synlab Medizinisches Versorgungszentrum Weiden GmbH, Weiden in der Oberpfalz, Germany
Research Article
Comparative LCMS/MS Drug Analysis of paired Urine, Oral Fluid and Capillary Blood Samples in Addiction Therapy
Author(s): Bernd Huppertz*, Michael Bottcher, Stefan Lierheimer, Prisca Gottwald, Sergej Bleicher and Martin Schafer
Background: For many years, drug of abuse analysis was typically performed on urine using enzyme immunoassays with Gas Chromatography–Mass Spectrometry (GCMS) confirmation. However, analytical instruments improved significantly over the last decades, allowing analysis of smaller sample volumes and other matrices, such as capillary blood and oral fluid, with lower drug concentrations. To our knowledge, the present study is the first to compare the matrices urine, capillary blood and oral fluid using similar analytical techniques and paired samples.
Method: Samples were collected from patients admitted for detoxification to Huyssens-Stiftung, Essen, Germany over a period of maximum 14 days. Each patient provided samples of all three matrices at almost the same time during each collection cycle. All analyses were performed with Liquid Chr.. View More»
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