Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh
Research
Duchene muscular dystrophy (DMD)/Becker muscular dystrophy (BMD): Genotyping and concept of prenatal diagnosis of Bangladesh
Author(s): Abdul Aziz*, Waqar A khan, Atokia Bilkis and Shahin Mahmud
Background: Duchenne and Becker muscular dystrophy (DMD/
BMD) are X-linked recessive disorders caused by mutation in
dystrophin gene. Patients with muscle weakness came to hospital
for improvement their child. Physician advice to dystrophin gene
analysis who have high Cpk (Creatine kinase) value and muscle
weakness.
Methods: We collected 61 DMD/BMD patient specimens for genetic
analysis in which three females were relatives. Multiplex polymerase
chain reaction was done for detecting deletion of dystrophin gene.
Results: The overall mutation detection rate was 72.4% (21/29) in
DMD/BMD patients, identifying deletions in 58.6% (17/29). Most of
the deletions were confined to the central hot spot region between
exons 44 and 55 (52.9%, 7/19).
Conclusion: In thi.. View More»
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