Department of Psychiatry, Southern Medical University, China
Review
In osteoporotic ovariectomized rats, bone-targeting PLGA-derived lipid treatment delivery system decreases bone loss
Author(s): Shashi Singh*
The distribution of anti-osteoporotic medications at the right dose has proven difficult due to the lack of safety, efficacy, and specificity. In our research, bone-specific polyaspartic acid Asp) 8-DNPs were added to cathepsin K inhibitor loaded poly derived lipid hybrid nanoparticles to cure osteoporosis. DNPs shown their affinity for binding to hydroxyapatite and were successful in releasing cathepsin K inhibitors over the course of up to 5 days. The tartrate-resistant acid phosphatase activity and resorption-related genes in osteoclasts were drastically reduced by cathepsin K inhibitor loaded Asp 8-DNPs. The tibia and femur of animals showed high levels of Asp 8-DNP accumulation, as well as increased trabecular bone mass and more organised three-dimensional architecture in osteoporotic rat models. Herein, the bone targeted drug delivery system show its potential in treatment of os.. View More»
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