University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur 492010, Chhattisgarh, India
Review
Development of Nanoformulations for
Targeted Transport of CNS Drugs with Greater
Pharmacological Activity via the Nose in to
the Brain
Author(s): Rajendra K Jangde*, Sulekha Khute, Harish Bhardwaj and Krishna Yadav
The purpose of the paper is actively exploring the feasibility of using nanocarriers in the brain to treat various neurological disorders. These include Parkinson’s disease, schizophrenia, epilepsy, Alzheimer’s disease, brain cancer, multiple sclerosis, depression, cerebral ischemia, and cerebral malaria. Among the various approaches available, nose-to-brain drug targeting remains the most acceptable but difficult challenge due to the complex structure and multiple barriers presented by the CNS. The various nanoformulations including microemulsions, nanoemulsions, polymeric nanoparticles, micelles, solid lipid nanoparticles (SLNs), liposomes, and transferosomes are currently used for their advanced delivery approaches. The nanoformulations are capable of performing the desired functions of the advanced delivery and targeting approaches, i.e., enhancing nasalto- brain deliv.. View More»
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