Department of Biophysics, and Structural Biology, University of Yale, United States
Editorial
Beyond the Norm: Unraveling Non-competitive Inhibition in Enzyme Kinetics and Drug Development
Author(s): Swastika Singh*
Enzymes play a pivotal role in catalyzing biochemical reactions, making
them critical targets for drug development. Traditionally, enzyme
inhibition has been categorized into competitive, non-competitive,
and uncompetitive inhibition, with non-competitive inhibition often
considered a less explored and enigmatic mechanism. This article
delves into the world of non-competitive inhibition, shedding light
on its unique characteristics and implications in enzyme kinetics and
drug development. Noncompetitive inhibition differs from competitive
inhibition, as it involves the binding of an inhibitor to both the enzymesubstrate
complex and the free enzyme, forming an enzyme-inhibitor
complex that cannot proceed to product formation. This distinctive
mechanism alters the kinetics of the enzymatic reaction, resulting in
decreased enzyme activity irrespective .. View More»
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