Health science and medicine Karolinska Institute, Sweden
Mini Review
Construction of Protein-Interactions Ontology
Author(s): Thomas Edison*
Protein-protein interaction (PPI) network architectures (maximal complete subnets) are a crucial tool for analysing protein complexes and functional modules. The data defection from biological studies is complemented by PPI prediction techniques based on cliques. Clique-based prediction techniques, on the other hand, simply consider the network's topology. In a network, false-positive and false-negative interactions frequently obstruct prediction. To address this issue and increase prediction accuracy, we provide an approach that combines the gene ontology (GO) annotations with clique-based method of prediction. We produce two predicted interaction sets that ensure the quality and amount of anticipated protein interactions based on several GO correction algorithms. The PPI network from the Database of Interacting Proteins (DIP) is subjected to the suggested technique, and the majo.. View More»
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