Department of Science, Academia Sinica, Taipei, Taiwan
Research Article
Biphase Drug Delivery Systems Carrying Nanocomposite Particles
Author(s): Thomas Ende*
Magnetite nanoparticles and poly (D,L-lactide-co-glycolide) (PLGA) were combined to create drug-carrying magnetic nanocomposite spheres for magnetic targeted drug delivery. Through the chemical coprecipitation of ferric and ferrous chloride salts in the presence of a potent basic solution, magnetic nanoparticles of magnetite (average size: 13 nm) were created (ammonium hydroxide). For the synthesis of nanocomposite spheres, an oil-in-oil emulsion/solvent evaporation process was used, with agitation lasting 1.5 to 2 hours at 7000 rpm. Specifically, acetonitrile (oily phase I) was used to dissolve the PLGA and drug, which was subsequently mixed with magnetic nanopa.. View More»
DOI: 1791-809X-14.08d-972
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