Department of Pharmacology, MET Institute of Pharmacy, Adgaon, Nashik, India
Research Article
Design and Evaluation of Gastroretentive Mucoadhesive Films of Rizatriptan Benzoate
Author(s): Ahirrao Sapana P*, Bhambere Deepak S, Patil Moreshwar P, Kshirsagar Sanjay J, Kanade Rupali N and Udavant Pavan B
Introduction: Mucoadhesives are synthetic or natural polymers, which interact with the mucus layer covering the mucosal epithelial surface and mucin constituting the major part of the mucus. The use of a mucoadhesive dosage form for drug delivery via the gastrointestinal mucosal route increases bioavailability and results in a longer therapeutic impact. Migraine is a prevalent headache illness that places a significant financial and social burden on both the patient and society. It is a puzzling condition characterized by pulsating headaches that are usually limited to one side and occur in bouts lasting 4 to 48 hours and is often associated with nausea, vomiting, sensitivity to light, vertigo, loose motions and other symptoms.
Material and Methods: The Rizatriptan is a selective 5- hydroxytryptamine receptor subtype agonist acute t.. View More»
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