Department of Science, Italy
Research Article
Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers
Author(s): Vig G*
In terms of delivery to the brain, the intranasal route is a highly promising route. Nevertheless, it is one of the most challenging and complicated routes. As a outcome, researchers are constantly looking for novel drug delivery vehicles like polymeric and lipid nanoparticles that are likely to improve the bioavailability of the drugs that are given to the brain.A certain number of publications from various databases and the literature were selected for this study.In order to investigate the published studies and demonstrate the superiority of nanocarriers in increasing the bioavailability of various drugs in the brain, meta-analyses employing two distinct algorithms (DerSimonian–Laird and inverse variance) were carried out.In addition, lipid nanosystems and polymeric nanosystems were quantitatively compared. After normalization, the meta-analysis used the important pharmacokin.. View More»
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