Mahakal Institute of Pharmaceutical Studies, Behind Air Strip, Datana, Dewas Road, Ujjain, Madhya Pradesh 456664, India
Mini Review
Novel Nano-Based Drug Delivery Systems for Fibrotic Liver's Hepatic Stellate Cells
Author(s): Vikas Jain*
Hepatic stellate cells (HSCs) are phenotypically active and develop a phenotype
resembling myofibroblasts in the perisinusoidal region of the liver. Affected hepatic
function, portal hypertension, increased vascular resistance; fibrosis, cirrhosis, and
hepatocellular carcinoma are all results of this phenotypic transformation, which
is also responsible for the accumulation and production of various extracellular
matrix (ECM) proteins in the perisinusoidal space. In the injured liver, the main
collagen-producing cells are activated HSCs/myofibroblasts. As a result, HSCs are
frequently the focus of fibrosis treatments. Since HSCs contain the majority of
the body's retinol, antifibrotic nanomedicine frequently target them with vitamin
A decorating. Transforming growth factor-beta, collagen, and connective tissue
growth factors are targeted by vitamin A-decor.. View More»
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