Neuroscience Research Institute, State University of New York College at Old Westbury, New York, USA
Research Article
The Role of Galanin, Conjugated Linoleic Acid, 12-O-Tetradecanoylphorbol-13-acetate and Molecular Docking of Treatments on Beta- Secretase 1 Enzyme: Effects of Inflammation on Alzheimer's Disease
Author(s): Chloe Liu* and Wei Zhu
Obese Alzheimer patients are at double the risk for memory loss compared to nonobese Alzheimer patients. Therefore a correlation between obesity and neuronal function as it correlates to memory loss pathology was investigated. This study also investigated the role of inflammation by exacerbating this pathology. MTT assay was used on 3T3 differentiated and undifferentiated cells treated with galanin, and its antagonist, M40, conjugated linoleic acid, and lipopolysaccharide to determine percent survival. LDH assay was used on 3T3 differentiated cells treated with Aβ40 and tetradecanoylphorbol acetate to determine cell cytotoxicity. Oil red staining of immune cells treated with galanin, M40, and conjugated linoleic acid were used to enhance cell imaging of lipid accumulation. 3T3 differentiated cells treated with conjugated linoleic acid in MTT assay had a 23.20% greater cell surviv.. View More»
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