Department of Biotechnology, University of Jerusalem, Israel, India
Research Article
Immunohistological Analysis of Cervical Cancer in Patients
Author(s): Yuri Sarma*
Our aim was to understand and analyse the expression intensity of selectively a singular gene (in our case, FANCC) which is a part of the DNA damage response pathways associated with cervical cancer. We performed
immunohistochemistry of six different slides obtained from CNCI hospital, out of which 3 were normal samples, while three were tumour samples. We analysed the expression intensity pattern for BRCA1, BRCA2, FANCC, FANCD2, DNMT1, DNMT2, MLH1 and MLH2 and primarily focused on FANCC in this report.
FANCC (Fanconi Anaemia complementation group)/FANC is a damage repair gene associated with the Homologous Recombination Repair pathway (HRR) that provides specific instructions for making a particular protein that is involved in one of the fanconi anaemia pathway. The FA pathway is activated when the process of DNA replication is blocked due .. View More»
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